Senior Scientist, Macrophage-Stromal Biology

Engitix Therapeutics is a pioneering biotech company dedicated to unlocking extracellular matrix biology to develop transformative therapeutics in fibrosis and oncology. We are seeking an accomplished Senior Scientist of Macrophage Biology to play a leading role in defining novel targets in the macrophage-stromal interface.

We are looking for an expert in macrophage biology, who will use their experience to establish a high throughput monocyte and macrophage supply chain for biology and drug screening groups across the Discovery unit. In addition, you will be a lead in the nomination and validation of new targets at the macrophage-stromal interface with the potential to deliver therapeutic impact in both oncology and fibrosis disease areas.

You will also be a key member of a team establishing macrophage-based target screening assays combined with our novel extracellular matrix-based cell models and will utilise cellular, immunological, biochemical, molecular biology and functional genomic approaches to validate drug targets and novel therapeutic agents.

• Establish high throughput supply of monocyte derived macrophages for multiple groups across the Engitix organisation
• Drive novel macrophage drug target nomination and validation
• Optimise co-culture assay systems based on stromal-macrophage interface in 2D and 3D platforms for drug screening
• Optimise macrophage target screening-based systems utilising functional genomic approaches such as siRNA and CrispR.
• Analyse, interpret, report and present results

• Demonstrable expertise in macrophage biology, in particular phagocytosis pathways
• Demonstrable experience in immuno-oncology and/or fibrosis research
• Expertise in the use of multi-colour flow cytometry and IF techniques on tissue sections
• Hands-on experience of key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT-PCR, western blotting, siRNA knockdown

• Familiarity with molecular pharmacology and oncology drug development
• Prior laboratory research experience in the biotech/pharma industry

• PhD in Biomedical Sciences, Immunology, Biochemistry, Biotechnology, or a related discipline, plus 3 years’ experience in a drug screening environment; or an MSc plus 6 years of practical experience with a focus on immuno-oncology or fibrosis
• Ability to plan, execute, and critically assess experiments independently
• Excellent time-management skills and ability to work to set deadlines
• Excellent written and verbal communication skills and the ability to work effectively within a team
• Strong troubleshooting skills, with a methodical approach, high attention to detail, and the ability to maintain accurate records

• Be part of a pioneering biotech transforming drug discovery through ECM biology
• Work in a collaborative, fast-paced environment with opportunities to shape the future of targeted therapeutics
• We offer a competitive package including private medical insurance, pension, bonus, employee perks and more