Scientist, Drug Discovery

London

Full-time

Permanent employee

Your mission

Engitix Therapeutics is a pioneering biotech company dedicated to unlocking extracellular matrix (ECM) biology to develop transformative therapeutics in fibrosis and oncology. We are seeking an accomplished Scientist to play a key role in the development and execution of biochemical and cell-based assays to support drug discovery activities

This is an exciting fully lab-based role in which we are looking for a scientist with strong experience in assay development within a drug discovery setting. You will contribute across the discovery cascade, from target validation through to biologics/small molecule profiling, to enable progression of therapeutic programmes. In this role you will apply innovative experimental approaches to interrogate pathway biology, validate novel targets, and characterise candidate drugs in fibrosis and oncology. Interest or experience in ECM biology is highly desirable.

Key Responsibilities:

Apply a range of molecular, cellular, and biochemical techniques to investigate mechanism of action and pathway biology
Design, develop, optimise, and troubleshoot robust biochemical and cell-based assays to support target validation, screening, and biologics / small molecule characterisation
Perform pharmacological profiling of compounds, including dose-response studies and data interpretation (e.g. IC₅₀/EC₅₀ analysis)
Establish and maintain mono and co-cultures of primary cells and cell lines
Contribute to ongoing research on oncology and fibrosis drug discovery projects
Independently analyse, interpret, report and present results

Your profile

Key Experience:

Demonstrable experience in cell-based and biochemical assay development within a drug discovery context
Experience generating and interpreting pharmacological data (e.g. dose-response analysis)
Experience working with primary cells and/or complex cellular systems (e.g. co-cultures)
Hands-on experience of relevant techniques such as qRT-PCR, ELISA/Luminex/MSD, western blotting, flow cytometry and cell-based functional assays
Practical experience in either immuno-oncology or fibrosis would be an advantage
Prior industry experience in biotech/pharma (2+ years) is strongly preferred

Qualifications and Competencies:

PhD in Biomedical sciences, Immunology, Biochemistry, Biotechnology or related discipline or MSc plus 2 years practical experience in cellular/molecular biology, molecular pharmacology or cancer/fibrosis biology
The post holder will be good at troubleshooting, methodical, well organised, pay close attention to detail, and maintain accurate records
Able to plan, execute and critically assess experiments independently
Excellent time-management skills and ability to work to set deadlines
Work well within a team and in matrix environment, with strong written and verbal communication skills

About us

Engitix is a growing biotech company based in White City Place, West London. We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform. Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.

Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.